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KMID : 0370220160600050235
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Yakhak Hoeji
2016 Volume.60 No. 5 p.235 ~ p.242
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Anti-inflammatory activity of the Fruits of Blue Honeysuckle
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Kim Jeong-Hwa
Jo Mi-Na
Han Ju-Hwan
Pyo Seung-Hyeon
Kim Tae-Soo
Kim Eun-Hee
Lee Jae-Kwon
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Abstract
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In this study, we demonstrated the anti-inflammatory activities of two kinds of blue honeysuckle (Lonicera caerulea var. edulis Turcz, Lonicera caerulea var. longibracteata f. ovata Hara) extracts in the LPS-stimulated macrophages. These two extracts showed non-cytotoxic activity, even at the high concentration. These two extracts of honeysuckle reduced the production of nitric oxide, cyclooxigenase-2 and pro-inflammatory cytokines. The inhibitory activities of two extracts of honeysuckle were found to be caused by blockage of NF-κB activation.
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KEYWORD
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Lonicera coerulea var, edulis, blue honeysuckle, anti-inflammation, macrophage, nitric oxide, cyclooxigenase-2
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